Loratidine  
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Contents on the CD Rom

  • Loratidine is a new generation antihistamine drug, used for treating various skin and other allergies.
  • Since Loratadine represents a “new generation” of antihistamine, it does not cross the blood-brain barrier and does not cause drowsiness.
  • Loratidine has a much longer lasting effect when compared to other antihistamines in use.
  • It is (H1) receptor antagonist, penetrates very poorly into the central system, hence is devoid of CNS depressant effects. Structurally it is related to azatidine. Loratidine also suppresses mast cell mediator release.
  • Loratadine, a member of the piperidine class of antihistamines, has gotten relatively positive reviews in particular for the treatment of feline itchy skin.
  • Loratadine, a long-acting tricyclic antihistamine, undergoes extensive first-pass metabolism in the liver to form its major metabolite
    desloratadine, which also possesses antihistamine activity and is subject to further metabolism.
  • A gastro retentive controlled release system of loratadine was formulated to increase the residence time in stomach and to modulate the release behaviour of the drug.
  • The preparation of colloidal particles of different morphologies, including spheres, of two drugs, loratadine and danazol, has been described.
  • The synthesis of two contaminants of Loratadine, generated when the product is formulated as a syrup.
  • India is set to rule the generics market for Loratidine, an anti-allergy drug, in the US.
  • Loratidine sales in the US, at $ 3.2 billion, account for 80 per cent of global sales.

General Information

  • Claritin
  • Showing drug card for Loratadine
  • Loratidine

Company Profiles & Consultant

  • Company from India
  • Company from China
  • Company from USA
  • Indian Company from Delhi
  • Indian Company from Maharashtra
  • Allergy and Asthma Disease management centre

Process

  • Effect of CYP2D6*10 Allele on the pharmacokinetics of loratadine in chinese subjects
  • Formulation and evaluation of oil entrapped gastroretentive floating gel beads of loratadine
  • Formulation of loratadine in to hydrogels
  • Preparation and coating of finely dispersed drugs. Loratadine and danazol.
  • Synthesis of 2- and 4-hydroxymethyl Loratadine, usual impurities in Loratadine syrup formulations
  • Next Generation Nanosuspension Processing for the Delivery of Non-Soluble Drugs
  • C-Solid state NMR study of loratadine polymorphism

Equipment Suppliers

  • HPLC with charged aerosol detection for pharmaceutical cleaning validation
  • Use of Acrodisc® Syringe Filters for Analytical Sample Preparation;
    Including HPLC and Dissolution Testing
  • A Varian UNITYINOVA- 400 (9.4 T)

Application

  • Fluticasone Nasal Spray and the Combination of Loratadine and Montelukast in Seasonal Allergic Rhinitis.
  • Interactions of the Nonsedating Antihistamine Loratadine with a Kv1.5-Type Potassium Channel Cloned from Human Heart
  • Pharmacokinetics of loratadine and its active metabolite descarboethoxyloratadine in healthy Chinese subjects
  • In Vitro Characterization of the inhibition profile of loratadine desloratadine and 3-oh-desloratadine for five human cytochrome p-450 enzymes
  • Simultaneous Determination of loratadine and preservatives in syrups by thin layer chromatography
Material Safety Data Sheet & Product
  • Safety data for loratadine
  • Allergy Relief Tablets
  • Apo-loratadine
  • Galpharm Non-Drowsy Allergy Relief
  • Loratadine 5MG/5Ml Syrup
  • Loratidine 10mg Tablets

Patent

  • Dry Syrup Containing Loratadine
  • Transdermal preparation contacting a loratidine metabolite with antihistaminic activity
  • Ophthalmic compositions containing loratadine
  • Process for the preparation of loratadine
  • Eyedrops

Market & Report

  • India to rule Loratidine's US market
  • Morepen to gain from loratidine's OTC status
  • Morepen aims for 40 pc of US loratidine market
  • Evaluation of an Association Between Loratadine and Hypospadias
  • Geneva Pharma retains loratidine exclusivity
  • Loratadine and Hypospadias birth defects study

Raw Material Suppliers

  • Water Suppliers from India
  • Water Suppliers
  • Ethanol Suppliers
  • Isopropyl ether Suppliers
  • Toluene Suppliers

Suppliers

  • Suppliers of Loratidine
  • Selling leads of loratidine
  • Loratidine Suppliers
  • Loratidine Exporters
  • Loratidine Manufacturer / Suppliers
  • Loratidine Chemical Suppliers

 

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