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Project at a Glance Contents on the CD ROM
  • Cholestyramine (CSM) is an FDA-approved medication used to lower elevated levels of cholesterol.
  • Cholestyramine is a quaternary ammonium anion exchange resin with a strong affinity for bile salts.
  • Cholestyramine is a co-polymer of styrene and divinylbenzine, its molecular weight is about one million and it is irisoluble in water.
  • Cholestyramine or colestyramine (Questran, Questran Light, Cholybar) is a bile acid sequestrant, which binds bile in the
    gastrointestinal tract to prevent its reabsorption.
  • Cholestyramine is a strong ion exchange resin, which means that it can exchange its chloride anions with anionic bile acids in the gastrointestinal tract and bind them strongly in the resin matrix.
  • Cholestyramine removes bile acids from the body by forming insoluble complexes with bile acids in the intestine, which are
    then excreted in the feces. When bile acids are excreted, plasma cholesterol is converted to bile acid to normalize bile acid  levels. This conversion of cholesterol into bile acids lowers plasma cholesterol concentrations.
  • Cholestyramine removes certain chemicals from the body which leads to more cholesterol being broken down. This lowers the level of cholesterol in the blood. Lowering cholesterol can prevent heart and blood vessel disease.
  • Cholestyramine is also used to treat severe itching caused by liver disease.
  • Cholestyramine can also be used to treat diarrhea.
  • Cholestryamine is also used to treat diarrhea-predominant IBS, cardiac glycoside toxicity, diarrhea associated with excess fecal bile acids (such as in patients with a resected bowel), and pseudomembraneous colitis.
  • Cholestyramine is used to treat the itching that occurs with certain types of liver disease. Itching occurs because of retention of bile salts which are made by the liver. Cholestyramine binds these bile salts in the intestinal tract, thereby reducing them in the blood and relieving the itching that elevated bile salts can cause.
  • Cholestyramine can affect how other medications work when taken at the same time. Take other medications 1 hour before or 4 to 6 hoursafter taking Cholestyramine.
  • Cholestyramine resin acts by releasing chloride and combining it with bile acids in the intestine to form insoluble, nonabsorbable complexes that are excreted in the feces along with unchanged resin. The excretion in the feces prevents the bile acids from returning to the liver by enterohepatic circulation.
  • Lowering the bile acid concentration in the hepatocytes causes an increased conversion of cholesterol to bile acids, resulting in a replenished supply of these compounds, which are essential components of the bile. This causes a decrease in the intracellular cholesterol concentration, which activates an increased uptake of LDL particles. The final outcome is a decreased plasma cholesterol concentration.
  • Cholestyramine (Questran) works by chemically binding the bile acids produced by the gall bladder.
  • Cholestyramine drug may interfere with the absorption and digestion of fats and fat soluble vitamins such as A, D, E and K. It may be necessary to supplement these vitamins as well as calcium and folic acid.
  • Cholestyramine has been
    used safely for over forty years in millions of patients who have taken the medication for extended periods of time.
  • Cholestyramine is one of the oldest and relatively safest cholesterol lowering medications on the market today.

General Information
  • Cholestyramine Information
  • Cholestyramine Basic Info
  • Cholestyramine Information Card
  • Questran Uses
  • Cholestyramine resin
  • Cholestyramine and its role in C. difficile infections
  • Questran (cholestyramine powder
Fact Sheet
  • Cholestyramine (CSM) Facts
  • Cholestyramine side effects Facts
  • Questran Fact Sheet

Data Sheet

  • Cholestyramine
  • Questran Lite
  • Cholestyramine Resin from Texas
  • Cholestyramine Resin USP
  • Cholestyramine Resin from USA
  • Cholestyramine from Germany


  • Duolite
  • Prevalite
  • Questran
  • Cholestyramine
  • Cholestyramine USP
  • Cholestyramine 5% Ointment
  • Cholestyramine Ointment
  • Cholestyramine Light
  • Cholestyramine Paste


  • Calorimetric evaluation of hydration of cholestyramine
  • The use of histological techniques for the
    demonstration of ion exchange resins
  • Production Cholestyramine via catalytic Green Copolymerization
    method in the presence of supported Heteropolyacids


  • Enhanced elimination of warfarin during treatment with cholestyramine
  • Cholestyramine Good for Diarrhea
  • Hypoprothrombinemic
    hemorrhage due to
    cholestyramine therapy
  • Doxepin-Cholestyramine Interaction
  • Arteriohepatic Dysplasia:
    A 16-Year Follow-up
    During Treatment With
  • Cholestyramine for Diarrhea
  • Questran available as Questran Lite
  • Report - Cholestyramine in uraemic pruritus


  • Effect of Cholestyramine on Bile Acid Metabolism in Normal Man
  • Hypolipidemic Effect of Flavonoids and Cholestyramine in Rats
  • Chronic diarrhoea in non collagenous microscopic colitis - Therapeutic effect of cholestyramine
  • Evaluation of the Effects of Cholestyramine on the Pharmacokinetics
  • Effect of cholestyramine on telepaque oral cholecystography
  • Bile acids and vitamin A absorption in man: the effects of two bile acid-binding agents, cholestyramine and lignin
  • Effects of Cholestyramine on Receptor-mediated Plasma Clearance and Tissue Uptake of Human Low Density Lipoproteins in the Rabbit
  • Effects of Cholestyramine on Low Density Lipoprotein Binding Sites onLiver Membrane
  • Effect of Cholestyramine on Fecal Excretion
  • Effects of cholestyramine on
    HMG-CoA reductase activity and low density lipoprotein receptor expression in gallstone patients
  • Effects of gluten free diet and cholestyramine
  • Effects of the Cholestyramine on the Induction of Intestinal Tumors in Rats by Azoxymethane
  • Effects cholestyramine on bile lipid composition in patients with hypercholesterolaemia
  • Effect of cholestyramine and Mevinolin on the diurnal cycle of rat
  • Effect of psyllium and
    cholestyramine in the hamster
  • Effect of Cholestyramine on the formation of pigment gallstone in high carbohydrate diet-fed hamsters
  • Effects of Cholestyramine and Diet on Small Intestinal
    Histomorphometry in Rats


  • Ability of cholestyramine resin to bind Escherichia coli enterotoxins
  • Prevention of Bile Reflux-Induced Acute Gastric Ulceration in the Rat by Cholestyramine
  • Utilization of cholestyramine resin as a preventive treatment for antibiotic induced enterotoxaemia in the rabbit
  • Cholestyramine Therapy for Dyslipidemia in Non-Insulin-dependent Diabetes Mellitus
  • Interruption of the Enterohepatic
    Circulation of Digitoxin by Cholestyramine
  • Low-Dose Therapy with Fluvastatin and Cholestyramine in Hyperlipidemic Patients
  • Pharmaceutical Applications
    for Ion Exchange Resins
  • Ion Exchange resins: Pharmaceutical applications and recent advancement
  • Clinical trials of cholestyramine


  • Edible, baked compositions containing cholestyramine
  • Psyllium cholestyramine compositions with improved palatability
  • Palatable cholestyramine granules, tablets and methods for preparation thereof
  • Edible, non-baked low moisture cholestyramine composition
  • Palatable cholestyramine coacervate compositions
  • Direct compression cholestyramine tablet and solvent-free coating thereof
  • Cholestyramine compositions and method for treating biliary gastritis
  • Cholestyramine compositions and method for preparation thereof
  • Composition containing cholestyramine and method of producing the same
  • Cholestyramine ointment to treat persistent diaper rash in an infant
  • Treatment of phenprocoumon
    intoxication with cholestyramine


  • Analysis of the In Vitro Interaction Between Vancomycin and Cholestyramine
  • Cholestyramine Powder in vitro Bioequivalence
  • Comparison of the In Vitro Activities of Teicoplanin and
    Vancomycin against Clostridium difficile and Their Interactions with Cholestyramine
  • Efficacy and Safety of Diclofenac-Cholestyramine in Osteoarthritis
  • Efficacy and Safety of Ursodeoxycholic Acid Versus
    Cholestyramine in Intrahepatic Cholestasis of Pregnancy
  • Intestinal obstruction association with cholestyramine therapy
  • Mathematical model and dimensional analysis of glycocholate binding to cholestyramine resin
  • Sodium Cholate Sorption on N-Octadecylpectinamide in Comparison with Cholestyramine


  • Absorption of Dietary Fats by the Rat in Cholestyramine-induced Steatorrhea
  • Cholestyramine and a Fat-Free Diet Lower Apolipoprotein A-IV mRNA in Jejunum of Rats
  • Catabolism of low density lipoproteins by perfused rabbit livers: Cholestyramine promotes receptor-dependent hepatic catabolism of low density lipoproteins
  • Cholestyramine resin ameliorates chronic aminoncleoside nephrosis
  • Cholestyramine Reverses Hyperglycemia and Enhances
  • Cholestyramine on Serum Lipids  in Hypercholestrolaemic Rabbits
  • Influence of changes in lipid values induced by cholestyramine and diet on progression of coronary artery disease
  • Cholestyramine inhibit the direct synthesis of low density lipoprotein apolipo protein B in miniature pigs


  • Mechanisms of Action of Cholestyramine in the Treatment of Hypercholesterolemia
  • Acipimox in combination with low dose cholestyramine for the
    treatment of type II hyperlipidaemia
  • Influence of Maternal Cholestyramine Treatment on
    Cholesterol and Bile Acid Metabolism in Adult


  • Cholestyramine suppliers
  • Suppliers for Cholestyramine
  • Cholestyramine suppliers
  • Suppliers for Cholestyramine

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