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  • Streptomycin is an antibiotic drug, the first of a class of drugs called aminoglycosides to be discovered, and was the first antibiotic remedy for tuberculosis. It is derived from the actinobacterium Streptomyces griseus. Streptomycin stops bacterial growth by damaging cell membranes and inhibiting protein synthesis. Specifically, it binds to the 16S rRNA of the bacterial ribosome, which prevents the release of the growing protein.
  • Streptomycin and various other antibiotics are produced using strains of Streptomyces griseus. Spores of this actinomycete are inoculated into a medium to establish a culture with a high mycelial biomass for introduction into an inoculum tank, with subsequent use of the mycelial inoculum to initiate the fermentation process in the production tank.
  • Streptomycin belongs to a group of compounds, known as antibiotics, which are produced by microorganisms and which possess the property of inhibiting the growth and even of destroying other microorganisms. Antibiotics vary greatly in their chemical nature, mode of action upon different organisms, and effect upon the animal body. The selective action of antibiotics upon bacteria and other microorganisms is known as the antibiotic spectrum.
  • Streptomycin was found to be soluble in water and insoluble in organic solvents, such as ether, chloroform, and acetone. The chloride was completely soluble in methanol, less soluble in ethanol, and virtually insoluble in butyl alcohol, acetic acid, and pyridine. The sulfate was only slightly soluble in methanol and virtually insoluble in the other solvents.
  • Streptomycin belongs to the glucosides in which a diguanido-group is linked to a nitrogen-containing disaccharide-like compound. It is a strong base, with three basic functional groups. The molecular weight determination on the trihydrochloride in water gave about 800 for the free base after the necessary corrections for the chloride ion.
  • Streptomycin is active against a large number of bacteria found among the gram-negative, gram-positive, and acid-fast groups and among the spirochaetes; it has relatively little activity against anaerobic bacteria, fungi, protozo, and viruses. No absolute value can be given for the sensitivity of an organism to streptomycin; this depends not only upon the particular species.
  • Streptomycin proved to be highly effective in the treatment of a large number of infectious diseases brought about in experimental animals by various bacteria. This was true of Salmonella schottmülleri, Shigella gallinarum, Brucella abortus, Pseudomonas aeruginosa, Klebsiella or Friedländer’s bacillus, Diplococcus pneumoniae, and a number of organisms commonly found in urinary tract infections.
  • Streptomycin is also used as a pesticide, to combat the growth of bacteria, fungi, and algae. Streptomycin controls bacterial and fungal diseases of certain fruit, vegetables, seed, and ornamental crops, and controls algae in ornamental ponds and aquaria. A major use is in the control of fireblight on apple and pear trees. As in medical applications, extensive use can be associated with the development of resistant strains.
  • Streptomycin and Rifampicin are potent antibiotic drugs. Streptomycin is broad spectrum drug effective against both gram positive and gram negative bacteria. However, its major use is as an anti-TB drug. Rifampicin also is used extensively as an anti-TB drug but it is also used in treatment of leprosy. As both the diseases are rampant in India, their importance can not be over emphasized.
  • India, today, is a major producer of streptomycin.Consumption has stagnated and is likely to decline in years to come. There is a considerable export market. However, Indian price of about Rs.l 100 per kg. is way above the international price. More potent drugs like rifampicin which are now available, are likely reduce the demand for streptomycin.
 General Information
  • Antibiotic
  • Streptomycin
  • Streptomycin sulfate
  • Chemical database of streptomycin
  • Streptomycin-A highly potent antibiotic
  • Streptomycin Molecule

Production Process

  • Streptomycin Production
  • Preparation of streptomycin
  • Extraction and purification of streptomycin
  • Stimulation of Streptomycin Production by a Series of Synthetic Organic Compounds
  • Nutritional requirements of streptomyces griseus for the formation of streptomycin


  • Biosynthesis of Streptomycin
  • Streptomycin Biosynthesis and Metabolism
  • Streptomycin biosynthesis - Reference pathway
  • The Biosynthesis of Streptomycin
  • Biochemistry and Regulation of Streptomycin and Mannosido -streptomycinase Formation
  • Streptomycin Biosynthesis
  • Studies on the Biosynthesis of Streptomycin

Company Profiles

  • GlaxoSmithKline plc.
  • Holdipharma
  • Kyowa Hakko Kogyo Co., Ltd.
  • Merck & Co., Inc.
  • Morsef Pharmaceuticals Private Limited
  • North China Pharmaceutical Huasheng Co., Ltd


  • Dennis I. Bojrab
  • Robert Thomas Sauer
  • Roger W. Jelliffe
  • J K Aronson
  • Yuen Kwok Yung
  • Experts in streptomycin

Material Safety Data Sheet

  • Streptomycin 17
  • Francisella tularensis
  • Bac-Master
  • Penicillin and Streptomycin Solution
  • Streptomycin sulfate
  • Vanguard® Plus 5
  • Safety data for streptomycin sulfate salt

Patent  and Technology

  • 2-deoxystreptomycin
  • Covalent microparticle-drug conjugates for biological targeting
  • Transposon tagging of genes in transformed plants
  • Derivatives of streptomycin and method of producing streptomycin derivatives by mutational biosynthesis
  • Variations in Strains of streptomyces griseus Isolated from a Degenerating Streptomycin-Producing Culture
  • Prevention of Loss of Streptomycin Production on Repeated Transfer of Streptomyces griseus
  • Effect of Penicillin on Streptomycin Production by Streptomyces griseus
  • Membrane-bound and extracellular b-lactamase production with developmental regulation in Streptomyces griseus
  • Chemical method for the determination of streptomycin in blood and spinal fluid
  • Accumulation of S-Adenosyl-L-Methionine Inhibits Sporulation in Streptomyces lividans TK23


  • Streptomycin Residues in Orchard Canopies
  • Pesticide Information Project
  • Sources and Acquisition of Streptomycin Resistance in Erwinia amylovora, the Fire Blight Pathogen
  • Management of Diseases of Tree Fruits; Fire Blight; Mildew
  • Development of a rapid screening method for the detection of multiple aminoglycosides
  • Revenge of the Microbes: How Bacterial Resistance Is Weakening the Antibiotic Miracle
  • The Rebuild and Expansion Project of the Animal drugs Factory of Xinjiang Western Animal Husbandry Co., Ltd.
Functions and properties
  • Locus of action of streptomycin in the development of clostridia from spore inocula
  • Acquisition of Certain Streptomycin-Resistant Mutations Enhances Antibiotic Production in Bacteria
  • Bacteriostatic Action of Streptomycin on Ribosomally Resistant Mutants of Salmonella typhimurium
  • Characterisation of streptomycin resistance determinants in Lithuanian Escherichia coli isolates
  • Defective Lysis of Streptomycin-Resistant Escherichia coli Cells Infected with Bacteriophage f2
  • Effect of Streptomycin Deprivation on Enzyme
  • Origin of the Guanidine Groups in Streptomycin
  • Isolation of Streptomycin-Nonproducing Mutants Deficient in Biosynthesis of the Streptidine Moiety
  • Effect of Streptomycin on Lipid Composition
  • Streptomycin Resistance in Mycobacteria
  • Background, isolation, properties, and utilization of streptomycin
  • Tuberculostatic and tuberculocidal properties of streptomycin


  • Streptomycin sulfate salt 
  • Penicillin-Streptomycin Mixture
  • Agri-mycin 17 agricultural streptomycin
  • Penicillin − Streptomycin − Neomycin Solution
  • Streptomycin Sulfate
  • EmbryoMax® ES Cell Qualified Penicillin-Streptomycin Solution


  • Streptomycin in the treatment of bone joint tuberculosis
  • Used to control fire blight of fruit trees
  • Uses of streptomycin in urology
  • Streptomycin Applications to Control Walnut Blight Disease
  • Effect of Streptomycin and Isoniazid in Pulmonary Tuberculosis with and without Para-Amino Salicylic Acid
  • Practical application of antibacterial drugs for the control of honey bee diseases
  • Streptomycin Blood Levels Following Inhalation of Steam Generated Aerosols


  • Overview of streptomycin market
  • Pesticide resistance: Prevention and Management Strategies 2005
  • Streptomycin Wonders
  • Drug market
  • Drug Pricing
  • Global Drug Facility tender results
  • Near-Term Market


  • Establishing links in the regulation of antibiotic production
  • Streptomycin and Streptomycin Sulfate
  • (Dihydro) Streptomycin/ Penicillin Combination Products and (Dihydro) Streptomycin Products
  • Sensitivity of the tubercle bacillus to streptomycin before and during specific therapy
  • Streptomycin; Tolerance Reassessment Decision  
  • Streptomycin in Tuberculous Meningitis Report of a case
  • Mycobacterium tuberculosis Drug Resistance
  • Report of the Food Quality Protection Act Tolerance Reassessment Progress and Risk Management Decision
    for Streptomycin
  • The Indian Journal of Tuberculosis report
  • Report on Streptomycin
  • Streptomycin- arrogance and anger
  • Gold standard for drugs
  • Multi-Drug Resistant Tuberculosis

Manufacturers and Suppliers

  • Ishita Pharma
  • Streptomycin exporters
  • Streptomycin suppliers
  • Rx Medicine Suppliers
  • Selling leads of streptomycin
  • Streptomycin manufacturers

Safety and Guides

  • Guide for chemical control of diseases and insects
  • Environmental Guidelines for Pharmaceutical Manufacturing
  • Indications, dosage of streptomycin
  • Streptomycin- drug information
  • Streptomycin Sulfate- drug information

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