- Cyclosporine, sometimes referred to as
"cyclsporin A," is an immunosuppresive agent produced by the soil fungus
Beauveria nivia. It initially attracted the interest of the medical
community in the management of organ transplant patients, as its
mechanism of immune suppression is unique.
- Cyclosporine is used to
prevent rejection of kidney, liver, and heart transplants. It also is
used investigationally to prevent rejection problems in bone marrow and
other transplants.
- Cyclosporine suppresses
the immune system's T-cells. Both the T-helper cell and the T-suppressor
cell may be affected. Cyclosporine also inhibits interleukins.
- Cyclosporin may be used
in combination with another immunosuppressant and a steroid
medication.
- Cyclosporine is
generally given once or twice daily depending on the disease being
treated.
- Sandimmune is a
soft-gel capsule form of cyclosporine. Absorption from the intestinal
tract can vary a lot and is incomplete.
- Cyclosporine is
distributed largely outside the blood volume.
- The production of a
nanosuspension is the transformation of a macrosized powder into a
mostly aqueous nanosized suspension.
- Cyclosporin A (CsA) is
a cyclic oligopeptide that possesses imunomodulating properties and
exhibits strong anti-allergic effects. The drug has been used in humans
after organ transplantation, and in the last two decades in human
dermatology for the treatment of psoriasis and AD.
- In the last few years,
there is a growing interest in the use of CsA to treat canine skin
diseases. The efficacy and safety of CsA for the treatment of AD in dogs
was evaluated in several trials.
- CsA at the dose of
5mg/kg was found to have mild adverse reaction, usually GI related, but
otherwise was well tolerated.
- Cyclosporine, used
originally to prevent the rejection of transplanted kidneys, continues
to be recommended for a variety of organ transplants. However, it has
proven effective in treating people with rheumatoid arthritis who have
not responded well to other medications as well as those with other
rheumatic conditions and severe forms of psoriasis.
- Renal transplant biopsy
is the gold standard for differentiating ailograft rejection from acute
tubular necrosis and cyclosponne toxicity.
- Side effects include
high blood pressure, kidney damage, tremors, headaches, seizures,
excessive hair growth, excessive gum growth, confusion, coma, and
gout.
- The demand for
Cyclosporin in the U.S. market is estimated at $450
million.
|
General
- Introduction
- About
Cyclosporin
- General
Information
- Patient
Medication
- Trade Names
- Cyclosporin ophthalmic
emulsion
- Medication
Manual
- Cyclosporin- For
Veterinary Information
- Heart Transplant
Production And
Processing
- Production and
characterisation by application of the optimised analytics
- Optimization of media
composition for the production of Cyclosporin A by Tolypocladium
species
- Phospholipid-Stabilized
Nanoparticles of Cyclosporine A by Rapid Expansion from Supercritical to
Aqueous Solution
- Process for
manufacturing Cyclosporin a by highly productive fusant strain
- Production of
cyclosporins by Tolypocladium niveum strains
- Mechanism of action of
Cyclosporin or tacrolimus
Technology
- Cyclosporin-A Enhances
Docetaxel-Induced Apoptosis through Inhibition of Nuclear Factor-kB
Activation in Human Gastric Carcinoma Cells
- Nanostructured
Lipid drug Carriers
- FDA panel knocks back
inhaled Cyclosporin
- Treatment of
Cyclosporine-Induced Gingival Hypertrophy
- Assessing New
Technologies
- Heart
Transplantation
- Liver Transplantation
in Children
- Drug Therapy in the
heart Transplant Recipient
Applications
- Cellular adaptations of
skeletal muscles to
Cyclosporin
- Medical
Applications
- Prediction of
Cyclosporine Dosage in Patients
- Protective effects of
Cyclosporin A on T-cell
- Cyclosporin A in the treatment of Atopic dermatitis in
dogs
- Calcineurin Inhibitors:
A Novel Approach to Canine Atopic Dermatitis
- Intradermal drug
delivery by low frequency sonophoresis
- A novel application of
cyclosporineAin nonmyeloablative pretransplant
Products
- Cyrin
- Cyclosporin
Capsules
- Gengraf
Cyclosporin
- Generic Capsules
- Gengraf Capsules
- Sandimmune Soft Gelatin
Capsules
- Neoral Capsules
- Neoral Soft Gelatin
Capsules
- Panimun Bioral
- Material Safety Data
sheet
Suppliers
- Cyclosporin A
Suppliers
- Suppliers in
China
- Suppliers In
Tradekey
- ecplaza
Suppliers
- Sandimmune Neoral
Suppliers
- Tradeleads
- Cyclosporin
Manufacturers
|
Company Profiles And Plant
details
- Pharmaceutical
Technology
- Fujian Kerui
Pharmaceutical Co., Ltd
- NeuroPharma
- Isotechnika Inc.
- Eastpro Technology
Inc
- Poli Industria
Chimica
- Novartis
- Paddock Laboratories
Inc.
- Syntetica Fine
Chemicals Inc.
- Adamed
- Panacea Biotec
- Lipid Technology
Consultants And
Projects
- D. Adu, MD, FRCP
- American Physiological
Society
- Lachman Consultant
Services Inc.,
- Expert Consulting And
Expert Witness Services
- Michele
Keane-Moore
- Jo Prang-Medicap
Pharmacy Center
- Ophthalmic Consultants
of Long Island
- Margaret D.Allen
- Management Of
Multifaceted Projects
- Referential Projects In
Pharmaceutical Industry
Patent
- Cyclosporin-based
pharmaceutical compositions
- United states Patent-
Microemulsion Concentrate Composition Cyclosporin
- Pro-nanodispersion for
the delivery of Cyclosporin
- United States Patent-
Liposome Mixture Containing Cyclosporin
- Pharmaceutical
composition comprising cyclosporin solid-state microemulsion
Markets
- RPG
Life to market Cyclosporin in US
- Second Chiron plant has
sterility problems
- Immunosuppression
Minimization: Current and Future Trends in Transplant
Immunosuppression
- Considering a Market in
Human Organs
- A Promising
Immunosuppressive Agent
- Global Pharmaceutical,
Biotechnology & Medical Device Conference
- Scope And Opportunities
Of Contract Research Services In India
Reports
- Allergan- 03 Annual
Report
- Brain Cyclosporine A
Levels Are Determined By Ontogenic Regulation Of Mdr1a Expression
- Cyclosporin whole blood
immunoassays
- Generic Version of
Neoral Receives FDA Approval for Transplant Patients
- Issues Analysis
Report
- The Transplant
Revolution
- 2002 Organ And Tissue
Transplant Costs And Discussion
- T-Cell
Depletion/Cyclosporine Equal to Methotrexate/Cyclosporine
Safety issues And
Guidelines
- Drugs And
Supplements
- Chemical
Database
- Difficult Asthma
- Medline Plus
Information
- Neoral Side
Effects
- Adult Nutrition
Guidelines
- Guidelines On Renal
Transplantation.
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