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Validamycin is a
agricultural antibiotic. All its molecules contain glucose.
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Validamycin solution is
brownish transparent liquid, and the technical product is a color-less
and odorless hygroscopic powder, soluble in water, dimethyl formamide,
insoluble in ethyl acetate, ethyl ether and petroleum ether.
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Validamycin is a kind of
agricultural antibiotic with good control on disease of fungi such as
sheath blight of rice, wheat and corn without pollution to environment.
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Validamycin A , a
commercially used agricultural antifungal antibiotic, is a
microbialderived pseudotrisaccharide, which contains a core
aminocyclitol moiety, validoxylamine A , and glucose.
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Validamycin is a water
soluble antibiotics produced by Strep. Hygroscopicus Var. Jinggangensis
Yen, which consists of six components named A, B, C, D, E, F
respectively. Validamycin A is the major active ingredient.
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Validamycin A is a member
of microbial-derived C7N-aminocyclitol family of natural products that
is widely used as crop protectant and the precursor of the antidiabetic
drug voglibose.
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A gene cluster
responsible for the biosynthesis of validamycin, an aminocyclitol
antibiotic widely used as a
control agent for sheath blight disease
of rice plants, was identified from Streptomyces hygroscopicus
subsp.
jinggangensis 5008 using heterologous probe acbC, a gene
involved in the cyclization of D-sedoheptulose
7-phosphate to
2-epi-5-epi-valiolone of the acarbose biosynthetic gene cluster
originated from Actinoplanes sp.strain SE50/110.
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ValG is a
glycosyltransferase (GT) that is responsible for the glucosylation of
validoxylamine A to validamycin A.
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A 45 kb DNA sequencing
analysis from Streptomyces
hygroscopicus 5008 involved in validamycin
A (VALA)
biosynthesis revealed 16 structural genes, 2
regulatory
genes, 5 genes related transport, transposition
/integration or tellurium resistance; another 4 genes had no obvious
identity.
-
China plays a major role
in antibiotics production. Antibiotics of industrial, agricultural and
medicinal significance like erythromycin, avermectin and validamycin
are produced in vast amounts every year. |
General
Information
- Validamycin Data Sheet
- Validamycin Chemical
Profiles
- Validamycin Pesticide
Information
Process &
Production
- Determination of the antibiotic
fungicide validamycin A in formulated products by micellar
electrokinetic chromatorphy
- Gene Cluster Responsible for
Validamycin Biosynthesis in
Streptomyces hygroscopicus subsp.
jinggangensis 5008
- Nucleotidylation of Unsaturated
Carbasugar in Validamycin Biosynthesis
- ValC, a New Type of C7-Cyclitol
Kinase Involved in the Biosynthesis of the Antifungal Agent Validamycin
A
- Production of Validamycin from
crude substrates by streptomyces hygroscopicus in an external-loop
airlift bioreactor with a low height-to-diameter ratio
Application
- Trehalase activity in plant tissue
cultures
- Foliar Spray of Validamycin A
or
Validoxylamine A Controls Tomato Fusarium Wilt
- Study on optimal production of
3-ketovalidoxylamine A
C-N lyase and glucoside 3-dehydrogenase by a
newly
isolated Stenotrophomonas maltrophilia
Analysis
- Catalytic Analysis of the
Validamycin Glycosyltransferase (ValG) and Enzymatic Production of
4″-epi-Validamycin A
- Functional Analysis of the
Validamycin Biosynthetic Gene Cluster and Engineered
Production of
Validoxylamine A
- Synthetic studies on the
validamycins. i. Synthesis of beta-D-glucopyranosylvalidamine: 1l-2-o-
(beta-D-glucopyranosylvalidamine)-1,3,4/2,6)-4-amino-6-hyroxylmethyl-1,2,3-cyclohexanetriol
Technology
- Antibiotic biosynthetic pathways
and pathway engineering—a growing research field in China
- HPLC analysis of trehalose and
other soluble carbohydrates from the leaf tissue of indica and japonica
rice varieties
- Quantitative analysis of
Valienamine in the microbial degradation of Validamycin A after
derivatization with p-nitrofluorobenzene by reversed-phase
high-performance liquid chromatography
|
Company Profiles &
Plant
- Company from Delhi
- Company from Hong Kong
- Plant from Orissa
Consultant
- Consultant from China
- Consultant from Delhi
- Consultant from USA
- Consultant from Oregon
- Global Consultant
MSDS
- Validamycin A sc 281183
- Validamycin A
Patent
- Antibiotic compositions containing
validamycin compounds
- Validamycin C, D, E and F
antibiotics
- Method for Producing a
Validamycin A analog and uses therof
- Valiolone, a method of preparing
it, and its use to prepare acarbose and voglibose
- Fungicidal Mixtures Of
Amidinylphenyl Compounds
- Valiolamine derivatives and
production thereof
Functions
- Effects of trehalose on gene
expression in Arabidopsis thaliana seedlings: a genome-wide
analysis
- Effect of Validamycin A on the Inositol Content
and Branching of Rhizoctonia cerealis and Other Fungi
- Inhibition of trehalose breakdown increases new
carbon partitioning into cellulosic biomass in Nicotiana tabacum
- Physiological implications of trehalase from
Phaseolus vulgaris root nodules: partial purification and
characterization
- Effect of Validamycin A on the Production of
Cellulase, Xylanase and Polygalacturonase by Rhizoctonia
solani
Suppliers
- Validamycin Selling
leads
- Validamycin Supplier List
- Validamycin Exporters
- Validamycin Manufacturer & Suppliers
- Validamycin Sellers
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