- 1,2,4-Triazole is one of a pair of isomeric chemical compounds
with molecular formula C2H3N3, called triazoles, which have a five-membered
ring of two carbon atoms and three nitrogen atoms.
- 1,2,4-Triazole is a basic aromatic heterocycle. 1,2,4-Triazole
derivatives find use in a wide
variety of applications, most notably as antifungals such as
fluconazole and itraconazole.
- 1,2,4-Triazoles can be prepared using the Einhorn-Brunner
reaction or the Pellizzari reaction.
- 1,2,4-Triazole, triazole alanine, triazole acetic acid, triazole
pyruvic acid and triazole lactic acid are the common metabolites
derived from triazole-containing fungicides that act by inhibiting
sterol synthesis.
- 1,2,4-Triazole, triazole alanine and triazole acetic acid are
the
commonly used names for IUPAC nomenclatures 1H-1,2,4-triazole,
1,2,4-triazolyl-3-alanine, and 1H-1,2,4-triazol-l-ylacetic acid
,respectively.
- These three metabolites commonly occur as plant or soil
metabolites and are collectively known as the “triazole derivative
metabolites”.
- Triazole alanine and triazole acetic acid residues are
primarily associated with plant commodities, while 1,2,4-triazole is
mainly associated with animal commodities, lesser amounts of this
compound being found
in plant commodities.
- The toxicological database for 1,2,4-triazole was sufficient for
the evaluation of this compound, while the toxicological databases
for triazole alanine and triazole acetic acid were more limited.
- The inhibition of Salmonella typhimurium by 1,2,4-triazole
appears to be mediated through an effect on L-cysteine biosynthesis.
- 0-Acetylserine sulfhydrylase A, the final enzyme in the
L-cysteine
biosynthetic pathway, was found to catalyze a reaction between
0-acetyl-L-serine and 1,2,4triazole, giving 1,2,4-triazole-1-alanine
as a product.
- In wild type S. typhimurium grown on 4 mM I,2,4-triazole, 97% of
the total 0-acetyl-L-serine synthesized in uivo is incorporated into
1,2,4-triazole-lalanine.
- 1,2,4-Triazole also significantly lowers
the levels of several of the enzymes necessary for sulfate
reduction.
- In vitro studies, using purified preparations of 0-acetylserine
sulfhydrylase A, revealed greater losses of triazolylase activity
than sulfhydrylase activity in the enzymes from both cysK mutants.
- Resistance to 1,2,4-triazole apparently
can arise from mutations leading to a preferential loss of
triazolylase activity or from mutations which diminish both
activities to the extent that high concentrations of
0-acetyl-L-serine and sulfide accumulate behind the sulfhydrylase
reaction.
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General
- Triazole
fungicide metabolites.
- One pot
procedure for trisubstituted 1,2,4-trizoles.
Use
- Use of
3-Amino-l,2,4-triazole To Reduce Body Catalase
Activity in Cancer Studies.
Products
- Cayman
chemical product information sheet.
- Product
information for 3-amino-1,2,4-triazol.
- Paclobutrazol data sheet.
- Rebetol
product sheet.
Synthesis
- Design,
synthesis and evaluation of 1,2,4-triazole derivatives as
antifungal.
- An Improved
Synthesis of 1,2,4-Triazoles using Ag2CO3.
- Synthesis and
insecticidal activity of 1,2,4-triazole derivatives.
- Synthesis of
1,2,4-Triazole-Functionalized Solid
Support and Its Use in the Solid-Phase
Synthesis of Trisubstituted
1,2,4-Triazoles.
- New
Regioselective Synthesis and Biological Activity of Substituted
1H-[1,2,4]Triazolo[3,4-c][1,2,4]triazoles.
- Synthesis of
some Antifungal and Anti-tubercular
1, 2, 4-Triazole Analogues.
- Electronic
Supporting Information
Hypergolic Ionic Liquids to Mill, Passivate, Suspend, and Ignite
Boron Nanoparticles.
- Systematic
Method of 1,2,4-Triazole.
Report
- Pesticide
residues
in food 2008.
- 1H-1,2,4-triazole.
- Structural and Theoretical Investigations of
3,4,5-Triamino-1,2,4-Triazolium Salts.
- Conclusion regarding the peer review of the pesticide risk
assessment
of the active substance tebuconazole.
- 1-(2',4',6'-Trinitrophenyl)imidazoles and -1,2,4-triazoles
as Energetic Materials.
- Ionic
Liquids as Energetic Materials.
- Method of
obtaining derivatives of 3,5-dinitro-1,2,4-tryazole.
- Triazaboles
and Related Triazole Derivatives of Boron.
Patent
- One pot
synthesis of 1,2,4-triazoles.
- Method of
producing 1,2,4-triazole.
- Preparation
of 3, 5-dinitro-1, 2, 4-triazole.
- 5-oxo-3-nitro-1,2,4-triazole in gunpowder and propellant
compositions.
- Phosphorescent light-emitting iridium complex containing
pyridyltriazole ligand.
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Suppliers
- Suppliers of 1,2,4-triazole.
- Manufacturers of 1,2,4-triazole.
- Selling leads of
1,2,4-triazole.
- Suppliers of China.
- Exporters of 1,2,4-triazole.
- List of
1,2,4-triazole
suppliers
- Suppliers of china1.
Company profiles
- Company from
Mumbai.
- Company from Gujarat
- Company from Zhuzhou.
Consultancy
- Consultancy from
London.
- Consultancy from
Gujarat.
- Consultancy from Shanghai.
- Consultancy from UK.
- Online consultancy
MSDS
- Safety data
sheet for 1,2,4-triazole-3-carboxamide.
- Coppeready
data sheet.
- 1,2,4-triazole data sheet.
- Safety data
sheet for 1,2,4-triazole.
- 3-mercapto-1,2,4-triazole.
- 1,2,4-triazole
pure data sheet.
- 1,2,4-Triazole, sodium derivative data sheet.
Research
- 5,5´-Dinitrimino-3,3´-methylene-1H-1,2,4-bistriazole
a Metal Free Primary Explosive Combining Excellent
Thermal Stability and High Performance.
- Acidic
properties of some 1,2,4-triazole derivatives in non-aqueous media.
- Asian
Journal of Biochemical and Pharmaceutical Research:A review on
1,2,4-triazoles.
- Synthesis, characterization and anticancer activity of
1,2,4-Triazolo
[3,4-b]-1,3,4-thiadiazoles on Hep G2 cell lines.
Study
- Incorporation of 1,2,4-triazole-3-alanine into a mutant of phage
lambda lysozyme containing a single histidine.
- Design
and synthesis of new 1,2,4-triazole derivatives
containing morpholine moiety as antimicrobial agents.
- Novel
1,2,4-triazole and imidazole derivatives of L-ascorbic and
imino-ascorbic acid: Synthesis, anti-HCV and antitumor activity
evaluations.
- Chiral
1,2,4-triazole derivatives as potential synthetic intermediates.
- Qsar study
1,2,4-triazoles using several physicochemical descriptors.
- Quantum
chemical studies on tautomerism and basicity
behavior of some 1,2,4-triazole derivatives.
- Silver
complexes of 1,2,4-triazole derived N-heterocyclic carbenes:
Synthesis, structure and reactivity studies.
- Studies on
the Mechanism of Inhibition of Salmonella
typhimurium by 1,2,4-Triazole
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